Association of SOD2 Mutation (c.47T > C) with Various Primary Angle Closure Glaucoma Clinical Indices

Association of Matrix Metalloproteinase-9 (MMP9) Variants with Primary Angle Closure and Primary Angle Closure Glaucoma

Shorter axial length observed in patients with primary angle closure glaucoma (PACG) might be due to altered matrix metalloproteinase-9 (MMP9) activity resulting in ECM remodeling during eye growth and development. This study aimed to evaluate common variants in MMP9 for association with PACG. Six tag SNPs of MMP9 were genotyped in a Chinese sample of 1,030 cases, including 572 PACG and 458 pri...

Association of eNOS polymorphisms with primary angle-closure glaucoma.

PURPOSE Recently, several studies have investigated genetic associations between Cytochrome P450 (CYP1B1), Endothelial nitric oxide synthase (eNOS), and Neurotrophin-4 (NTF4) with primary angle-closure glaucoma (PACG) in various ethnic groups. We investigated the association of these candidate genes with PACG in samples from Australia and Nepal. METHODS A total of 235 patients with PACG (106 ...

Primary Angle Closure Glaucoma

Primary angle-closure glaucoma

The picture of primary angle-closure glaucoma accompanied by its shallow anterior chamber is so distinct that for many years it has evoked considerable curiosity concerning possible genetic determination. Family trees were published (Sedan and Sedan-Bauby, 1949; Waardenburg, I96I) and attempts were made to fit the inheritance into a genetic pattern-but without convincing success. Authors seemed...

Increased iris thickness and association with primary angle closure glaucoma.

AIMS To investigate the relationship between quantitative iris parameters and angle closure disease. methods: Participants with angle closure were recruited prospectively from glaucoma clinics. Anterior segment optical coherence tomography (AS-OCT) was performed under standardised dark conditions. Customised software was used on horizontal AS-OCT scans to measure iris thickness at 750 um...